Originally Posted by
datlas
Interesting. We don't see Cushing's much in humans, and the treatment 98% of the time is surgical resection of the adrenal tumor. I did not know it's more common in dogs.
Of course, we see iatrogenic cushing's syndrome more often, from use of steroids.
p.s. I had to look up trilostane, I figured it was some type of cortisol blocker or inhibitor of its synthesis...it was apparently used in humans in the past but withdrawn from the usa market in 1994.
Very common in dogs, usually a functional pituitary microadenoma. Sometimes a macroadenoma, that's when I get involved. Pro tip: if someone brings you their dog repeatedly insisting it's just "vaguely not right" or "a little mental" and you can't find anything, just go ahead and MRI the brain. Good chance you'll find a pituitary macroadenoma or other diencephalic lesion. It's a classic history starting with "No one believes me..."