What is the pedal situation on each bike and do you dress differently? If you're wearing a barn jacket, jeans and Clark's when you ride your hybrid and lycra and cleats when you ride your road bike, that'd do it.

If you're not riding fast, under 20 or especially under 16 mph, rolling resistance (not wind) is a big factor. If you're not dressing differently or using clipless pedals on the road bike but not the hybrid, it probably has a lot to do with your tires, the condition of your chain and all the bearings (hubs, bottom bracket, pedals). Does the hybrid have tire tread?