I agree, a lot depends on your goals.
I put a 25mm Marathon onto the rear of my bike for this winter.
And, got my first flat within the first 50 miles.
The next flat was on the front with a well used Origin8 Elimin8er.

The Schwalbe will be put into storage this spring, replaced with a Gator Hardshell, or perhaps grinding down the Elimin8ers a bit more.

Did you mention.
On roads?
Off Road/Gravel?
USA?
Loaded? Total Weight (person + cargo) Front/Rear?
Unloaded hotel hopping?

Some of my longest rides were on some pretty questionable quality sewups quite some time ago.

I'm now a big fan of puncture resistant tires, but the list is pretty long.