If you are asking if you would feel the difference between two tubesets that have the same diameters and wall thicknesses but different manufacturers, for example, Tange vs Reynolds, you won't. If you are comparing a standard sized straight gauge 4130 to an otherwise identical double oversize hardened tubeset, you probably feel a difference. However, as the article suggests, it's hard to predict which one you will like more. Then, start throwing design and construction differences into the mix and the watters become even more muddy. Every frame is different and every rider is different.