I have some of those ergon with integrated bar ends. I like the much better than the round grips I had before...but I don't ride anywhere near 50-100 miles at a time, so these may not be much better. I also have put a set of aero bars on my hybrid, so that gives me a third position.

Honestly, if I was going to ride 100 miles, I would get a road bike with drop bars. At some point, body ergonomics play a bigger role. Riding with your palms down simply puts more stress on your fore-arms than riding palms facing each other (as in riding on hoods). Over longer rides, that matters more and more. That's probably why you like the bar ends...it's the same hand position, except that bar ends are generally less comfortable than road bike hoods, AND, on a hybrid, they are too wide to be comfortable long-term.