Joined: Nov 2006
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From: NJ, NYC, LI
Bikes: 1940s Fothergill, 1959 Allegro Special, 1963? Claud Butler Olympic Sprint, Lambert 'Clubman', 1974 Fuji "the Ace", 1976 Holdsworth 650b conversion rando bike, 1983 Trek 720 tourer, 1984 Counterpoint Opus II, 1993 Basso Gap, 2010 Downtube 8h, and...
Okay, assuming a large wheel (700c or the like) and a conventional hub (flanges no larger than, say, 7 cm) I don't think it'll matter. On such wheels spokes rarely break anywhere other than the bend at the head.
In contrast, when you build a large hub into a small wheel you can get a rather extreme bend at the nipple. Under such circumstances spokes often break right where they exit the nipple (assuming tabgent lacing, of course). As long as that's not what you're doing, I think you'll be okay.
You might want to get extra long nipples, just to be sure.
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