Originally Posted by Mr. Shadow
Odd/even combos like the formentioned 46/17t will extend chain wear.
A combo that doesn't divide evenly will extend tire wear (more skid patches). However, both 46/16 and 46/17 give a lot of skid patches, so that's pretty much negligible.
I vote for the 16; I'm pushing a 48/16 and I'm no champ.