Too funny you guys,,,

OP You will notice a real difference if you go to the 44 tooth, Don't go for any more.

I can mash my top gear on my 27.5 Inch tire bike,, That's a 42 up front and 11 on the cassette.
Mines a 27.5" bike remember ?...
I am faster on the next larger (13) tooth cassette cog when on the big ring and THIS gear I can sustain for a quarter mile or so.

My old 29er Hard Tail Scott had a 42 tooth chain ring. I used it but never used the smallest two cogs on the cassette...The 29er wheels,, well....
I'm not that strong.
Mashing like that can destroy your knee's over time,,,