I tend to be freshest after a 3 day rest. One or two days off are also good, but longer than three is worse. OTOH, I can also ride day after day with little built up fatigue, but by about day six a day off makes me fresher.
When I used to do tours riding about 100+ miles daily, I'd usually plan a soft day every 5 or so.
BTW- Sometimes you don't need an off the bike day to recover, just an easy ride day, where you're still riding, but not working anything hard.
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