OK I'll step up to the plate. I run a 48 tooth biopace chainring and a 17 tooth cog. Its my main ride. The trick is to set the chain tension a tad bit tight, with the cranks vertical. That is where you'll get the most tension. Then turn the cranks 90 degrees and you'll see that its a lot of slack. Its not a problem. I rarely use my brake, but I don't skid or skip. I've been riding this setup for about 2 months and have yet to have a single problem. I wouldn't worry about it. Just run what you want!