I test rode a Domane 4.5 and the 5.2. But the 4.5 was a larger size and we had to adjust the seatpost down for me. It did feel a bit lifeless to me; the 5.2 felt a lot better. The 4.5 was at the LBS while the 5.2 I rode was at one of the Trek Demo Days events.
But the 5.2 has a different carbon mix, different wheels, tires, components, etc.
All I can really say is that, FOR ME, I greatly preferred the 5.2 over the 4.5. Which is why I stress to the OP that he not dismiss any bikes based on forum opinions but go test ride them for himself.
Next year, Trek will release its new gravel bike, the Damone.