Originally Posted by gorshkov

It isn't clear exactly what advice you're looking for - do you want suggestions on how to get between each successive pair of places?

I haven't toured in any of those places except the Great Smokies and Washington DC, and I took a very different route that didn't go through any of the other locations on your list. So I can't help you much with routing, other than to note that the Appalachians have some very steep hills, and you'll want to keep that in mind when you plan routes.

Another bit of advice: I wouldn't recommend KOA for a bike tour (or tent camping in general). You're better off camping in state parks, forests, etc. It will usually be quieter, cheaper, and more scenic.