I ride a 53t biopace with a 17t EAI cog.
I set the tension at 1/8" at the tightest spot and about 5/8" at the loosest spot.
That puppy won't come off no matter what I do.

It takes the same number of watts to climb a hill or push the wind out of the way, no matter what kind of chainring a rider has.
That said, I find the biopace much more elegant and expecially so on hills where I have to get out of the saddle.
I only wish the biopace came in more offerings.