With a double cross chaining should not be an issue. If the chain is rubbing the front derailleur and trimming does not fix it, there is an adjustment problem. I've used all the gears with no issues. Cross chaining was never an issue on any of my doubles regardless of the number of cogs. However, I've never ridden the newer 10 or 11 speed bikes.

I can adjust the triples on our touring bikes so there is no chain rub in any gear combination. However, cross chaining is not recommended even though it will not cause a problem if used only for a brief period.