What is your loaded weight?
I am a bit under 350, and on my PDG 70 series, I run a Kenda Kwest K193 100 psi 40-559 on the rear, and a Nashbar City Slick 100 psi 32-559 on the front, both on Velocity Aeroheat (18mm inside width) rims. I have over 1000 miles on this combination - no issues at all, just pump them up once a week. They both still have mold flash in the tread area.