Ability to mount 28mm at least or 32mm properly and also naturally to fit the frame is critical. I only run 70-80 PSI.
For rear wheels I have three that get Rando use. 28H Flo30, 21H Dura-Ace C50, or 32H A23 on Dura Ace hubs. The only wheel that ever needed any minor truing is the 32H hub and its sister up front is not true to my liking having suffered a trip up Rt 32 in Bucks County Pennsylvania. I am barely no longer a Clyde and these wheels have proven themselves to my liking although I don't trust the 32H wheels for a long ride. My front wheel is always 20H Flo30. I have a set of 48H Phil hubbed wheels on my ancient Rando bike.
The only time I have hit serious potholes has been when I was mindlessly following other riders's wheel. With good lights mounted in the right spot, I can see potholes fine.... Well, Vermont was just one big pothole.