Interestingly, the triple version of that crank calls for a NDS spacer between the cup and arm -- presumably to make sure the arm is still spaced out far enough to clear the chainstay:
http://www.shimano.com/media/techdoc...9830616000.pdf So there is a precedent for scootching the things around with this system. But that document also says not to use the small ring with the three smallest cogs, so...
I'm not as familiar with the HT style cranks, so the only question I have is whether the inner cover thing would still connect properly with both BB cups if the DS cup is now 2-2.5mm further away.
Other things to consider: whether you need a 52T/53T big ring. If you substituted a 48T or 50T, there would be less potential for the chain to rub when in the small/smaller cog combinations, because the diameter of the big ring would be smaller.
If it were a friction-shifted front, I'd consider adding thin spacers between the small ring and crank arm in order to scootch the two rings apart, which would increase the chain angle on the small/smallest gear combos, but would reduce/prevent the rub. That might mess up the front shifting though.