Yes, you need to think about the wheels. "Full specs" says 26 spokes, but I count 24 front, 28 rear. I'm at 250 myself, and would not consider less than 32 spokes in the rear. You can go less in the front because that always bears less weight. But still I think 24 would maybe be pushing it.
You have a few options:
* When you get the bike, take the wheels to a local shop (do you have a local shop? Or is no local shop the reason why you're ordering online?) and have them make sure the spokes are properly tensioned and de-stressed. If set up as well as possible, such a wheel may be able to serve you.
* If you bring the whole bike in, the shop may well try to sell you a new bike inspection/tuning. It's not a scam, but depending on your own bike servicing skills, and your luck of the draw for factory assembly, it may or may not actually be a good value for you.
* So you could chance it with the stock wheels, ride 'em til they die (rear spokes start breaking), which could be in 100 miles, could be 1000s of miles, and then buy replacement wheels.
* Or you could buy replacement wheels up front, and sell the stock wheels while they are still in brand new condition. One very common low cost commuting wheelset recommendation is the
Nashbar Vuelta Corsa HD. Their weight will a little bit counteract the lighter weight of the Defy you liked, if you want to shed weight and keep strong, you'll have to pay more money. If you watch Nashbar, their prices will go up and down a little as they have various sales, keep an eye out for free shipping offers.