No backpack is going to be as comfortable as using on bike storage.

http://www.amazon.com/gp/product/B00...ustomerReviews

I commute and tour on a road bike using one of those.

If I were going to commute to a job and had to bring my laptop to and from, and for some reason couldn't leave it at the work place, I would use that rack and bungee cord any old piece of **** backpack to it, with the laptop inside.

That way my back won't be covered in sweat when I get to work.