I was riding when I was over 400lbs. I like this saddle:
http://www.amazon.com/Schwinn-Deluxe...n+cruiser+seat I used it for several years when my weight was between 350 and 400 and it held up. Now I weigh less but the saddle is still comfortable.
I know a lot of people don't think padded saddles are a good idea, but personally I end up with bruises on my butt from the firmer saddles...I've tried for a couple months before to see if I could get used to it and I just have a black-and-blue butt the whole time, never toughen up like people say should happen.