175lb rider...18lb bike...
I typically ran my 23mm Pro 4s at a punishing 100-110. After doing some reading, I decided to mess around a bit with these numbers a bit last night. Ran my rear at 100 and my front at 85. Smoother ride for sure and that I noticed, zero difference i handling. Out of saddle, hard acceleration, cornering...all seemed the same by the chatter through my hands on crappy roads seemed subdued.
I'm going to fool around with it a bit to see what I can find but it's a cool idea running the at different pressures.