I have only done mini tours, bike camping trips, and my daily commute on my Vittoria Hypers. I've been running them for about 4 years, although they were called something else when I started.

I looked through my order history, and I would say that I have been replacing them every 3 or 4 thousand miles. Rough estimate because I don't keep very careful track of my mileage.

They replaced my Marathon Plusses and were immediately a hit. Supple and fast rolling and so much lighter than the Plus (as every tire is). The first was on experiment, and after a few weeks I ordered a 2nd, so I could get rid of the Plusses entirely. I was determined that they felt good enough to ride on that I would suffer through the flats. But that didn't really happen. I probably get more flats on the hyper, but that seems to work out to be one or two flats a year rather than 1 or 2 every 2 years. I originally thought that having a "flat-proof" tire would outweigh all other considerations, but it didn't take long for me to change my tune.

If I were flatting out every month or so, I might consider switching to something with more protection, but the Vittoria Hypers have been great, and I haven't considered ditching them yet.