6', 200# here. I bought a large 2014 Defy 5 last October or so, and changed out the stock saddle almost immediately, numbness being the main issue.

My first replacement saddle was a Brooks, which was good at the beginning of a ride...exhibiting much less numbness... but it routinely became painful in the sit bone area after 30-40 miles. I gave it about 300-400 painful miles before I decided it wasn't going to work for me. (My daughter loves it on her bike though.)

I then went on to a free Diamondback saddle equipped with a longitudinal indent that I thought might help the numbness and the sit bone pain. It helped with both enough that I thought a full cutout might be the solution.

A $20 Craigslist Specialized Phenom with full cutout came next. It was somewhat better, but the sit bone soreness routinely became a sit bone rash after 60-70 miles, even when slapping on some pre-ride Bagbalm. At this point, I probably had logged 1,500 miles trying out these different saddles, but the pain was not going away and I was beginning to doubt that I hadn't given my ass enough miles to toughen up.

I thought I hit the jackpot with the Defy's current saddle, another Craigslist-purchased Specialized Romin....nearly no sit bone pain and very little rash even after a full century. I was getting ready to equip all of my bikes with one, when...

...about a month ago I bought my factory-build Surly 29+ hardtail kitted up with an el cheapo Velo 2155 'comfort' saddle. Holy crap, the thing nearly disappears under me, even on a 50-60 mile pot-hole ridden gravel logging road ride. I was stunned. No pain, no numbness, no rashes or skin rubbing off. Of course, on these gravel roads my cadence is much, much slower than when I'm hauling flat out on pavement with the road bike, so that might have something to do with it as well. Still, its got me thinking in different directions again.

Point being to all of this wordiness, once you've got the height, tilt and forward to back stuff squared away, and it still doesn't feel quite right, a new saddle might in the end just be the option the works out best for you. And it might not always be the most expensive one out there. If you've got some cyclist friends, see if you can borrow a few different types and see what direction you think your butt is telling you to move in before you start shelling out money for new saddles.

Keith