My semi-OT bike with 50mm Campy Bullets is not so bad in a cross wind, but is an extreme handful going into the wind downhill. Every small shift of the breeze is felt.

By comparison my 32 and 36 spoke C&V wheels are actually worse in a cross wind, but are very well mannered on descents. IMO spoke count is one of the most significant factors that influences everyday riding speed (fewer being faster). Bladed spokes seem significantly better in a cross wind than non bladed ones, not sure why, but it is noticeable.