I live in Boardman, OR and Goatheads are as plentiful as some of the cash crops.
I went tubeless with the Schwalbe Pro 700x23mm tires.
not only does the sealant in the tire seal small punctures say from goat heads, but no tubes mean no pinch flats for me if I go slowly over a railroad track or hit a bump.
I love the ride quality of these tires too.