Yeah, I found it out accidentally. I had installed a new saddle and the amount of pressure on my hands was good and I felt very balanced, however the nose was a tiny bit high irritating the soft tissues down below. I lowered the saddle nose, what I thought was a tiny amount, and noted the pressure below was relieved, but suddenly there was a lot of pressure on my hands that wasn't there before. I adjusted the nose up even a tinier amount and got it "just right".

I was surprised by how little saddle adjustment can affect the fit.