Devil is going to be in the details. So hard to generalize, but I will any way.

"comfort" or endurance bikes tend to have taller head tubes, which make them easier to set up in a more up right riding position, which tends to be the biggest difference.

A number of such models will have various geometry changes that tend to make the bike more "stable", i.e. more wanting to track straight ahead, as opposed to quick to turn.

These can include shallower head tube angles, more trail, longer seat stays.

So in general the more comfort oriented bikes will tend to setup higher, and will not be as "twitchy"