The likely answer is yes. Because of the randonnering we do, most of our road bikes are equipped with large rear cogs and they need MTB derailleurs; the shifters are either Ultegra or Tiagra (old bike).

It's the front derailleur that causes issues if it's an MTB one that you're trying to match with road shifters, because of the different cable pull or distance required to move the derailleur between rings.