Originally Posted by
Looigi
For best LiIon life: Use until about 50% discharged and wait just before use to recharge. I approximate this as best as reasonable with my stuff and don't sweat it too much. e.g. My f/r blinkies have about 7 hrs of life. I might do two rides totaling ~4 hrs, then charge them up the morning of (or night before) the third ride. I usually don't charge the Garmin until it's about 1/2 down. Same with my phone.
LiIon is 4.2 volts. You can't get a protected battery to discharge to that low a voltage! Battery University has good info on prolonging battery life for many different battery chemistries.
How to Prolong Lithium-based Batteries - Battery University