Being a gear tinkerer by genetic predisposition, I tinker and customize with almost all gear. It may be that after trying a number of different saddles, a good and workable one will be found. Then again, hundreds of dollars could flow out trying different saddles with no success at all. I have found, for me anyway, that too much padding becomes uncomfortable on longer rides. Very little padding is also uncomfortable. I now use a worked over saddle where I've removed some padding under the sitbone area and most of the padding further forward.
Furthermore, my position has altered in the last year and a half and 5000 miles or so. I now sit with the saddle quite far back, the bar further forward and slightly lower with the result that there is less weight and little discomfort on hands as well on the saddle itself. This is all due to the compulsion to tinker with what was not too bad to begin with. It demonstrates to me how integrated position, comfort and power delivery are. I'm not a powerful cyclist so every bit of help I can get is needed.