Yep. You should start out with it level. When your crotch starts hurting, pull over and bring the nose down about 1mm (or vice versa if you're sliding forward). Just a tiny amount almost hard to see with the naked eye. Not every saddle is the same. On my three road bikes, two saddles are curved and one is flat with a cutout. All three are different widths. One is slightly nose down, one is perfectly level and one is nose up about one degree. I can do century ride on all of them with no pain.

If tilt adjustments don't get it perfect you can try lowering your saddle a hair and that can take pressure off your sitbones when you're pedaling. Mine are about 1.5cm lower than the calculations say it's supposed to be, not everyone has the same skeletal structure. At that height I feel like I'm sitting in the saddle and not on it, if that makes sense. It feels good. It's possible your saddle is too high right now.