According to Cateye's web page, the Padrone uses Bluetooth LE sensors. So, No it will not work. However, if all you have is a speed sensor for the Padrone, any Bluetooth LE speed/cadence sensor should work with that unit. To make sure, I would take the computer to a bike shop and see if they will let you pair it to a Bluetooth sensor (if they have any in stock). If it works, and you want cadence, rather than spend money on a speed/cadence sensor, check out the Wahoo RPM. It's a Bluetooth cadence sensor that mounts on your crank or on your shoe.