I prioritize front cargo on my commuting & utility bikes for the simple reason that the front wheel is inherently stronger (on a rear derailler bike with its narrowed, dished rear wheel) and carries a lighter load when no cargo is added. The majority of my broken spokes and other wheel issues have been on the rear wheel, over the years, so it's not an imaginary problem.
On a couple of bikes I have acquired or built extra strong 40 and 48 spoke rear wheels, which help address the strength vs load imbalance.
Regarding handling, added weight on the front tends to increase longitudinal stability, while detracting from agility, obviously.