I've been experimenting with Strava Route Builder. It uses the Strava Heat Map of popular biking roads, and can make some reasonably good routes quickly.
See my previous review post
here.
I tried to click Delaware then Omaha, but that was probably too far. So I tried again, Delaware to Cincinnati, then a second click at Omaha. It doesn't look bad. The routing through southern Ohio and western Indiana is mostly good to excellent. But there's a few short, steeper climbs that can be avoided. And a couple of the roads are kind of bad for bikes, but the alternative routes are quite a big detour.
For me, the advantage is picking reasonable routes off the main highways in areas that I don't know. But these routes really need to be uploaded to a GPS, split into smaller sections. Look at the cue sheets, there's a lot of turns!
The maps can be edited by dragging a point on the route to a new road or city. It'll reroute to include that spot.
Here's the link:
DE to NE