Disc brake road bikes are a work in progress, standards are changing all the time and something you buy this year may be obsolete a couple of years from now. Buy a frame only if you already have most of the components you will need. If I were in the market for a disc brake road bike I would look at this: ANDANTE 2 - Endurance | Opus Bike
Canadian company, so prices are in Canadian dollars. Buying from anywhere in the US is terribly expensive right now with the dollar trading at under 70 cents US