If it doesn't have the self-adjusting feature of leather (and it doesn't), it's just another shape in the multitude of shapes available with minimum or no padding. It becomes a matter of detailed fitting of a particular design to one's anatomy.

I'll be ordering soon a Brooks B17 most likely with the cutout (is there anyone who tried the cutout and didn't like it? Please speak up...).

I have a Serfas Rx 921L, which I like, but past 25 miles starts giving me a burning/friction sensation at the contact points. Also, the frame is attached with a few Allen screws which seem to loosen with use and creak. I am not sure how much life is left in them after I re-tightened them a few times already...