Yes it is worthwhile. Near magic shifting properties. Especially for less experienced riders; more experienced riders say they can shift as fast or faster than e-shifting, but for most, it is revelatory. Don't ride it if you can't afford it because you will want it.

They need proper set up, but are nearly set and forget regarding adjustments, since most shifting adjustments are based on cable tension which does not exist with e-shifting. If adjustment is needed, it is a simple process to dial it in with a forward control.

Repairs, whether mechanical or e-shifting, are usually a replace, rather than repair kind of thing, and e-shifting units are significantly more expensive. And there's battery charge to worry about. Not to mention a wiring harness -- only an issue if you are considering the build yourself.

I just saw a YouTube vid of wireless SRAM e-shifting. Sexy!

It really depends on what you're after and a personal decision regarding $$$ v. functionality. Some say it's worth the money and any associated hassle regarding the electronics, others refuse to pay a premium when you're getting nearly the same performance cheaper with top line mechanical setups.