Bought the Fizik R5B's site unseen. My Specialized SPD shoes are a size 42 so that is what I ordered. Shoes fit well but feel long due to the carbon sole (no flex). Shoes have velcro toe straps which I have not moved and a Boa adjuster located at the top of foot that is intended to tighten mid and top portion of foot. Works great and I have adjusted tightness during my ride which was a snap. As mentioned earlier, shoes are extremely light. Much, much lighter than what I have been using. Plenty of room in the toe box, and heel position is perfect. I would say, out of the box, these shoes are super comfortable. One review I read stated that they got even more comfortable after the third time wearing them...I am looking forward to that since as is they are pretty damn good right now.
Looks wise, they look incredible. Even my boss was wowed by them when he saw them out of the box (had them delivered to my office). I paid $166 for these from Amazon. I was considering the Specialized Expert shoe as my other option. I am very happy with my choice.