My wife and I do loaded tours on our tandem. We weigh, all up, about 370#. For paved roads, we prefer 36H Kinlin XC 279 rims, double butted 14-15 spokes, and whatever hubs you can afford. We have Chris King. We run 28mm tires at 120 lbs in the rear, 110 lbs. front. We've had good experiences with Vittoria Rubino Pro Tech tires for touring at this weight. We use rim brakes, but going into unknown terrain with unknown gradients, we mount a wheel with a drum brake. For a single bike that heavy, at least a big rear disc would be a good idea if steep descents might be encountered.