I would have disagreed up to just a few months ago when I bought a new saddle. On my stock saddle, I would be ready to get off the bike at 2 hours with about the 2.5 hour point being extreme discomfort (needing to stand to relieve pressure very often and easing back down on the saddle to suffer finishing the ride and get the heck off the bike kind of discomfort.) This wasn't getting use to it, this was after having the bike and stock saddle for 2 years.

I've had the new saddle for 2 months with very little riding in. Saturday I was out for 9 hours, 5.5 hours of that being continuous riding (2.5 hours halfway for ridiculous restaurant lunch service.) I was 100% comfortable for the entire 5.5 hours in the saddle. Leaning on and fatigue in the arms for that long and the soreness in the legs the following day having doubled my previous longest ride is a different story, but being on the saddle for 65 miles was no problem whatsoever.