I think it just depends on terrain like hub spinner said. I have always had a mountain bike triple so the bike i have now, 50 34t compact is a first. It took me a while to get used to the jump between 34 and 50, it certainly is large. But i studied the gear ratios (stock cassette is a 12-30, but I'd prefer something like 12-27 or 28) and i shift small ring, and gears 30-15 then I have met a gear that my 50 ring matches. So i upshift to the 50 and down shift back a few gears and I am right at a similar gear ratio and moving up the 50.
I think it goes without saying that my 2x10 obviously doesn't cover the gaps like a 3x10 or 3x11 would, but the 2x10 is sufficient for my needs. The biggest concern I have is trying to avoid adverse chain angles. I am contemplating switching down to a 44 or 46 large ring but I just love getting in my powerful gears going down hill.