The wheel reflectors are not a good idea from a dynamic point of view, but if your ride at night.... visibility is key to safety. There are many ways to increase nighttime visibility like a tail light, helmet or bar mounted light, reflective tape on your bike and reflective clothing on your body. A new paint was developed that is invisible to the eye during the day but makes the whole bike reflective at night.
Do a little research and see what works best for you. Maybe a combination of a few available items, but wheel reflectors would only be my choice if I had no other choice. My shoes, tape on pedals, clothes and lights (front and rear) help make me visible and sometimes, to a texting driver who isn;t looking at the road...... no amount of reflection will help you!
Ride smart, do your best to be visible and live to ride another day