Reminded me of
this test from Velo News. I have the Thomson setback that I've used on the CAADX build I had and on the Crockett right now. It does pretty well, mainly because there is a massive bend that gives it a small point of relief. It's been comfy overall, but both bikes have seen most of their miles on 32mm tires. A straight masterpiece? It was nearly at the top of the list. I have one on my frakenbuild right now, but I haven't gotten to put any miles on it, yet. It's going to have 26 x 1.5 tires anyway. I'm more worried about the steel frame and fork that weigh 8 pounds.
But just look at a straight masterpiece and a setback you can guess which will be more harsh. Imagine two carbon forks, but one is curved and the other is straight. Physics and all that jazz.