I love my Lynskey R330 (from 2009). In November it will be 7 years old and I've got just over 35,000 miles so far. It's stiff, comfortable and light enough for me. And with a little Lemon Pledge, it cleans up well and looks virtually brand new! I bought it as my last bike and at 54 yrs old, it might very well be my last.
But......if I had to replace it, since the R330 is no longer made, I think I'd be tempted by a Moots Vamoots or a Vamoots RSL.
But (again)...if money were no object....I'd definately get the Ti bike that I've lusted after for years - a Baum Corretto.