The tire thing makes sense. I've been on my 4000's and going over to Thickslicks... that theory holds water. The wheels didn't seem heavier but I checked specs and they actually are.
That being said, technique-wise... what do you recommend? What can I do to get used to this set up, coming over from road riding? Are we talking something more along the lines of foot position? A different approach to cadence? Standing out of the saddle more?
How can I pedal more efficiently and come at least close to the acceleration and control I get in clipless pedals?