I would have no problems riding my bike at night in the city, near the train station. I would avoid areas like the upper part of Smallmen St because of it's concentration of bars. We have had problem in this area in the past with knuckleheads shooting people.

There are a couple of new hotels on the lower part of Smallman that I would have no issues riding to at night. There is also the Westin which is directly across the street from the train station and one or two other hotels very close by. Sadly nothing affordable.