I had gotten back into riding about 6 years ago and just went out and ordered a bike that was in the price I was comfortable with and went with what the size the chart said sight unseen. I rode it for short periods about 15 / 20 miles or so. A few years go by and I started to train for a 80+ mile ride so I started to put in 30 - 40 miles and subsequently more time in the ride. I started to get neck pain from looking up so I got a 30 degree angled stem which helped raise my upper body but not enough. This year I was searching YouTube for bike fitting videos and I came across one where a young girl was getting a fit (the thumbnail I'm sure generated lots of hits on the video). When I looked at this I immediately thought this is how I want to sit on a bike and this person was on a road bike with drop bars. Basically I want my head upright enough to not bend which is about a little greater than a 45 degree angle with respect to parallel to ground and thus my search for an "endurance geometry" bike. I bought an endurance frame that felt good on the 20 minute test drive but again after about an hour and a half the neck hurts a bit. I got another angled stem (17 degrees) and now I'm pretty good for about 3 hours or so. I agree with the other posts regarding some exercises and I would throw in the idea of stretching out the neck muscles prior to the ride and when the roads clear stretch it during the ride. The other thing I'll have to throw in there is that with getting into better shape now and peddling a little harder more consistently it's easier to keep my core in a better position and keep weight of my wrists/hands. Peddling as it turns out keeps weight off the arms and in turn allows less vibration traveling up into the spine.