Very interesting thread. I just went through 3 tubes in a row on my road bike (700x23 tires). First was a staple in the tire. Fresh tube on the side of the road, CO2 cartridge, made it home 12 more miles. Made it to work and back the next day ~30 miles. That night I decided to fully deflate the tire and reinflate since I've heard that CO2 leaks out faster. Inflated to 100psi and a few minutes later I noticed it was flat flat. Tube blew out on the rim side about an inch long blowout. Then the replacement I put in did the same thing, then the replacement the bike shop put in did the same thing (with new rim tape installed). Verdict was tires are too loose on the rims (no need for tire spoons at all they just slip on and off). So most recent tube was installed very carefully and inflated slowly to make sure the tire was seated properly and tube was in the right place. Did a metric century on it yesterday with no issues. I've never experienced something like this in all my years of bicycling but I'm learning something new every day