I'd definitely recommend 559 wheels for a smaller frame; you can buy tires (I read) as narrow as 25 mm/1" if you have the need for speed. 559 might look more proportional there also. 559 gives one the option to have S&S couplers; 622 mm/700C wheels don't fit into the case easily. BTW while I haven't tried hydraulic disc brakes, you might consider them since Pennsylvania has hills & rain.

I'm riding 56 cm Surly Disc Trucker with 559 mm (26") wheels. I recently bought the 50 mm Supremes on recommendation from another poster: they are light for the size, roll surprisingly fast, handle confidently & are the most comfy tire I've used on a touring bike.

That Pangea has a kewl paint job but no discs anyway.