When I get to the point where I have to replace the drivetrain on my road bike, I'm seriously thinking about taking it from 10 down to 8 sprockets on the rear. Seriously, I have NO need for 10. I sometimes shift a gear and can't even tell if it shifted or not without looking.
I also don't use the granny ring on the front anymore, because it requires a long cage derailleur, and when I wrecked mine last year, I found I could get short cage ones for $20 on eBay, while long cage ones were $50 and up. I never used the granny anyway, I doubt it's ever had the chain touching it.
8 is plenty for me, and the drivetrain components last a LOT longer. I just need to do some work to convert the indexing properly.
Also the parts are cheaper. 7/8 chains are $6 on sale and last longer. 10 chains are usually $18 and up unless there's a really good sale.
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Work: the 8 hours that separates bike rides.